In this episode, I’ll discuss why vaccines shouldn’t be given in the 14 days immediately post-splenectomy.
This recommendation is based on a small study of 59 splenectomy patients where vaccine response at 1, 7, and 14 days post-splenectomy were compared.
Better functional antibody responses against the serogroup and serotypes studied seemed to occur with delayed (14-day) vaccination. In fact, with one exception, all titers for the 14-day group approached those of the control subjects.
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