Direct Oral Anticoagulant Interruption Calculator If you are a human and are seeing this field, please leave it blank. Select an anticoagulant ApixabanDabigatranEdoxabanRivaroxaban Enter patient characteristics Age (years) Weight (kg) Creatinine Clearance (mL/min) No data on edoxaban half-life in clcr < 30 mL/min. Consider calculating as if clcr = 30 mL/min and that half-life will be somewhat longer than reported. Estimated Half-life (hours) Low bleeding risk procedure Withholding by 2 or 3 half-lives results in 25% or 12% residual anticoagulant effect, respectively. 2 Half-lives (hours) 3 Half-lives (hours) High bleeding risk procedure Withholding by 4 or 5 half-lives results in 6% or 3% residual anticoagulant effect, respectively. 4 Half-lives (hours) 5 Half-lives (hours) Evidence Prescribing information and other articles: Apixaban and edoxaban Dabigatran Rivaroxaban If you are a human and are seeing this field, please leave it blank.