In this episode, I’ll discuss the recent reports by the NIH and Gilead on the efficacy of remdesivir. Subscribe on iTunes, Android, or Stitcher Back in episode 486 when discussing medications with in vitro but otherwise unproven efficacy against COVID-19, I mentioned that efficacy data for remdesivir was expected in April 2020. The NIH met […]
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Episode 499: What is the Clinical Effectiveness of PCC in Factor Xa Inhibitor-Related Intracranial Hemorrhage?
In this episode, I’ll discuss an article about using prothrombin complex concentrates for the treatment of factor Xa inhibitor-related intracranial hemorrhage. Subscribe on iTunes, Android, or Stitcher Article Factor Xa Inhibitor-Related Intracranial Hemorrhage (FiX-ICH): Results from a Multicenter, Observational Cohort Receiving Prothrombin Complex Concentrates Lead author: Nicholas G. Panos Published in Circulation April 2020 Background […]
Episode 498: NIH Guidelines on Therapeutic Options for COVID-19
In this episode, I’ll discuss the new NIH guidelines on therapeutic options for COVID-19. Subscribe on iTunes, Android, or Stitcher On April 21, the NIH published expert consensus guidelines on the treatment of COVID-19. As these guidelines are evidence-based, and we have not had enough time for the rigorous testing of therapies against COVID-19, there […]
Episode 497: Can the Tisdale Risk Score be used to identify ICU patients at risk of QTc prolongation?
In this episode, I’ll discuss whether the Tisdale Risk Score can be used to identify ICU patients at risk of QTc prolongation. Subscribe on iTunes, Android, or Stitcher The Tisdale Risk Score (TRS) was first published in 2013 as a way to identify hospitalized patients at risk for QT interval prolongation. The scoring system assigns […]
Episode 496: Can alteplase be used to treat COVID-19 patients with thrombotic disseminated intravascular coagulation?
In this episode, I’ll discuss whether alteplase can be used to treat COVID-19 patients with thrombotic disseminated intravascular coagulation. Subscribe on iTunes, Android, or Stitcher Many patients severely ill with COVID-19 develop a thrombotic disseminated intravascular coagulation. Fibrinolytic therapy has been studied in patients with acute lung injury previously, and several hospitals are currently enrolling […]
Episode 495: AHA and ACC Presidents offer advice on QTc interaction between hydroxychloroquine and azithromycin
In this episode, I’ll discuss advice given by AHA and ACC Presidents on QTc interaction between hydroxychloroquine and azithromycin. Subscribe on iTunes, Android, or Stitcher As discussed in episode 488, there is tremendous interest in combining hydroxychloroquine and azithromycin for the treatment of COVID-19 based on a small French observational study. Performing a risk:benefit analysis […]
Episode 494: What to use for acute asthma exacerbation if you run out of MDIs?
In this episode, I’ll discuss what to use for acute asthma exacerbation if you run out of MDIs and can’t use nebulizers. Subscribe on iTunes, Android, or Stitcher Many hospitals are prohibiting nebulizer use during the COVID-19 pandemic to protect staff from disease transmission during this aerosol-generating procedure. This has led to the increased use […]
Episode 493: Can hydromorphone infusion be used in ventilated ICU patients?
In this episode, I’ll discuss whether hydromorphone can be used as a continuous infusion in place of fentanyl for ICU patients on a ventilator. Subscribe on iTunes, Android, or Stitcher Some hospitals are being faced with supply shortages of critical medications such as fentanyl, and are faced with using less ideal alternatives for continuous sedation […]
Episode 492: Do unused and unopened medications that have been in COVID-19 patient rooms need to be discarded?
In this episode, I’ll discuss the CDC Guideline for Disinfection and Sterilization in Healthcare Facilities and how it may pertain to unused and unopened medications that have been in COVID-19 patient rooms. Subscribe on iTunes, Android, or Stitcher Avoiding bringing medications into rooms with COVID-19 patients until they are ready to be used is the […]
Episode 491: Pharmacy-related COVID-19 updates
In this episode, I’ll discuss pharmacy-related COVID-19 updates. Subscribe on iTunes, Android, or Stitcher Hydroxychloroquine and chloroquine FDA Emergency Use Authorization The FDA has issued an Emergency Use Authorization for hydroxychloroquine and chloroquine to be used in patients with COVID-19. The FDA has also prepared patient and health care provider fact sheets. If you are […]
Episode 490: Which vasopressor should be discontinued first?
In this episode, I’ll discuss the discontinuation order of vasopressors. Subscribe on iTunes, Android, or Stitcher The first two vasopressors generally used to treat septic shock are norepinephrine and vasopressin. The usual strategy is to add vasopressin to norepinephrine. But what happens when the patient recovers and vasopressors need to be weaned? There is little […]
Episode 489: Pharmacy-related recommendations from the surviving sepsis COVID-19 critical care guidelines
In this episode, I’ll discuss pharmacy-related recommendations from the surviving sepsis COVID-19 critical care guidelines. Subscribe on iTunes, Android, or Stitcher The Surviving Sepsis Campaign has published guidelines on the management of critically ill adults with COVID-19. These guidelines were last updated on March 20th 2020. Information and recommendations are changing rapidly in this area […]
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