In this episode I’ll: 1. Discuss an article about piperacillin-tazobactam pharmacokinetics in critically ill patients. 2. Answer the drug information question “How quickly must dantrolene be accessible to treat a case of malignant hyperthermia (MH)?” 3. Share a resource about false positive urine drug screens. Subscribe on iTunes, Android, or Stitcher The article for this […]
Episode 182: Alternative anticoagulation strategies for continuous renal replacement therapy during the calcium shortage
In this episode, I’ll discuss alternative anticoagulation strategies for continuous renal replacement therapy during the calcium shortage. Subscribe on iTunes, Android, or Stitcher According to the ASHP current drug shortages list, both calcium chloride and calcium gluconate are in short supply due to manufacturing delays. The “local anticoagulation” method of using citrate during continuous renal […]
Episode 181: Antibiotic de-escalation in septic patients, is linezolid ever bacteriocidal, and financial advice for pharmacists by a pharmacist
In this episode I’ll: 1. Discuss an article about antibiotic de-escalation in septic patients. 2. Answer the drug information question “Is linezolid ever bacteriocidal?” 3. Share a resource about financial advice for pharmacists by a pharmacist. Subscribe on iTunes, Android, or Stitcher The article for this episode recently appeared in a weekly literature digest for […]
Episode 180: Pain assessment and treatment in ICU patients unable to communicate verbally
In this episode, I’ll discuss three different pain assessments to use in ICU patients who are unable to verbally communicate pain. Subscribe on iTunes, Android, or Stitcher The use of pain assessments for patients who are unable to verbally communicate are recommended in the SCCM Pain, Agitation & Delirium Guidelines. There are 3 main pain […]
Episode 179: Pharmacists decrease infection-related mortality almost as much as vitamin C, thrombolytics for PE if the patient is on apixaban, and idstewardship.com
In this episode I’ll: 1. Discuss an article about antimicrobial stewardship and empiric antibiotic timing. 2. Answer the drug information question “Should a patient on apixaban at home who presents with massive PE receive thrombolytic therapy?” 3. Share a resource for infectious disease pharmacotherapy. Thursday April 6, 2017 members of my Critical Care Pharmacy Academy will […]
Episode 178: Healthcare-Associated Ventriculitis and Meningitis Guidelines
In this episode, I’ll discuss the IDSA Healthcare-Associated Ventriculitis and Meningitis Guidelines. Subscribe on iTunes, Android, or Stitcher These guidelines were published in February 2017 Empiric therapy For empiric therapy in healthcare-associated ventriculitis and meningitis, select an agent that has CNS penetration and bacteriocidal activity against MRSA and pseudomonas. This will ensure coverage against the […]
Episode 177: Vitamin C, hydrocortisone, and thiamine for severe sepsis and septic shock
In this episode, I’ll discuss the recent study of vitamin C, hydrocortisone, and thiamine for severe sepsis and septic shock. Subscribe on iTunes, Android, or Stitcher Article Hydrocortisone, Vitamin C and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study Lead author: Paul E. Marik Published in Chest December 2016 […]
Episode 176: Double anaerobic coverage
In this episode, I’ll discuss double anaerobic coverage. Subscribe on iTunes, Android, or Stitcher Anaerobic pathogens Anaerobic pathogens are found in the mouth and the lower gastrointestinal tract. Oral anaerobes are the gram positives Peptococcus and Peptostreptococcus. Intestinal anaerobes are Fusobacterium, Prevotella melaninogenica, and more commonly Bacteroides fragilis. Oral anaerobes are easily covered with penicillins […]
Episode 175: Effectiveness of conivaptan and tolvaptan in neurocritically ill patients, carbamazepine plus oxcarbazepine, and a resource that helps justify alternate dosing schedules for meropenem and cefepime
In this episode I’ll: 1. Discuss an article about the effectiveness of conivaptan and tolvaptan in neurocritically ill patients. 2. Answer the drug information question “Is concomitant carbamazepine and oxcarbazepine therapy always a therapeutic duplication?” 3. Share a resource that helps justify alternate dosing schedules for meropenem and cefepime. Subscribe on iTunes, Android, or Stitcher […]
Episode 174: Tapering medications in the ICU
In this episode, I’ll discuss medications commonly tapered in the ICU. Subscribe on iTunes, Android, or Stitcher Three classes of medications that are frequently considered for tapering in the ICU are: -Corticosteroids -Opioids -Benzodiazepines For each of these classes, I will cover why, when, and how to taper them: Corticosteroids Why taper corticosteroids Corticosteroids are […]
Episode 173: Ciraparantag/PER977 to reverse edoxaban, how to relower serum sodium if it is corrected too fast, and a resource for intranasal medication delivery
In this episode I’ll: 1. Discuss an article about the anticoagulant reversal agent ciraparantag / PER977. 2. Answer the drug information question “How can serum sodium be re-lowered if hyponatremia is corrected too fast?” 3. Share a resource about intranasal medication delivery. Subscribe on iTunes, Android, or Stitcher Article Single-dose ciraparantag safely and completely reverses […]
Episode 172: Should SSRIs and SNRIs be discontinued in the setting of active bleeding?
In this episode, I’ll discuss whether selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) should be discontinued in the setting of active bleeding. I am excited to announce that I have teamed up with the Wegman’s School of Pharmacy St. John Fisher College to offer ACPE Continuing Education credit for listeners of […]
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