In this episode, I’ll discuss whether giving an antibiotic IV push affects the pharmacodynamic exposure.
Does giving an antibiotic IV push affect the pharmacodynamic exposure?
This question was examined for meropenem, cefepime, and aztreonam in a study published in American Journal of Health-System Pharmacy May 2017. In this study, previously published pharmacokinetic data for meropenem, cefepime, and aztreonam was used. The authors performed Monte Carlo simulations of 30-minute and 5-minute infusions to assess the probability of attaining appropriate time above MIC for each antibiotic. The authors noted no to minor differences between 30-minute and 5-minute infusions for most dosing regimens. Therefore there appears to be no concern from a pharmacodynamic standpoint of giving these antibiotics IV push.
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